Colonization by Pneumocystis jirovecii and Its Role in Disease

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Pneumocystis jirovecii colonization in Chronic Obstructive Pulmonary Disease (COPD)

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Pneumocystis jirovecii colonization in chronic pulmonary disease

Pneumocystis jirovecii causes pneumonia in immunosuppressed individuals. However, it has been reported the detection of low levels of Pneumocystis DNA in patients without signs and symptoms of pneumonia, which likely represents colonization. Several studies performed in animals models and in humans have demonstrated that Pneumocystis induces a local and a systemic response in the host. Since P ...

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pneumocystis jirovecii colonization in chronic obstructive pulmonary disease (copd)

chronic obstructive pulmonary disease (copd) is associated with a chronic inflammatory response in airways and lung parenchyma that results in significant morbidity and mortality worldwide. cigarette smoking considered as an important risk factor plays a role in pathogenesis of disease. pneumocystis jirovecii is an atypical opportunistic fungus that causes pneumonia in immunosuppressed host, al...

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Pneumocystis jirovecii colonization in Chronic Obstructive Pulmonary Disease (COPD)

Chronic obstructive pulmonary disease (COPD) is associated with a chronic inflammatory response in airways and lung parenchyma that results in significant morbidity and mortality worldwide. Cigarette smoking considered as an important risk factor plays a role in pathogenesis of disease. Pneumocystis jirovecii is an atypical opportunistic fungus that causes pneumonia in immunosuppressed host, al...

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Low Titer Pneumocystis jirovecii Infections: More than Just Colonization?

Non-pneumonia Pneumocystis jirovecii colonization is thought to occur frequently in immunocompetent individuals. The aim was to analyze if P. jirovecii low-titer detections have more impact than just colonization. From our total cohort of patients for which P. jirovecii testing by qPCR was requested, we selected exclusively those that were fully immunocompetent. Patients were defined as fully i...

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ژورنال

عنوان ژورنال: Clinical Microbiology Reviews

سال: 2012

ISSN: 0893-8512,1098-6618

DOI: 10.1128/cmr.00013-12